Despite their significant efforts, women’s contributions to household work are not formally recognized or calculated in the national economy in developing countries like Bangladesh. Their capacity and role became particularly noticeable during the COVID-19 pandemic when many women entrepreneurs became involved in Facebook-based (F-Commerce) businesses. This study explores the challenges and prospects of women in digital entrepreneurship, with a specific focus on F-Commerce in Bangladesh. The findings reveal that limited access to finance, digital literacy gaps, cyber harassment, and logistical inefficiencies, etc. are major constraints for women entrepreneurs. However, continuous efforts in business, adoption of digital strategies, engagement, with community groups, and the development of innovative products and services enable women to sustain and expand their businesses. As there are significant projects to grow favorable policies and collaborative efforts among stakeholders can further accelerate the growth.