This chapter begins by asking what drives success in a YUCA world, and by emphasizing resilience as the key. It discusses an integrated framework that uses three pillars of resilience, namely, strategic agility, sustainability, and organizational culture. It suggests that strategic agility enables quick adaptation and innovation amid environmental complexity. Sustainability aligns profitability with environmental and social goals through ESG practices, stabilizing volatility. Organizational culture fosters trust, transparency, and safety, anchoring ambiguity. The chapter uses case studies of organizations to illustrate how these elements reinforce each other to boost their long-term performance. This chapter redefines resilience as a strategic and ethical imperative, which guides leaders to turn disruption into opportunities for the renewal of organizations and their vitality in a non-linear world.