Aluminum alloy honeycomb sandwich panels are widely used in aerospace, transportation, construction engineering, and protection fields due to their performance advantages such as light weight, high strength, impact resistance, and thermal insulation. However, the phenomenon of sandwich layer infiltration is inevitable in liquid or gas environments, and in engineering, it is often necessary to perform slotting treatment on the honeycomb core to achieve timely drainage. This article investigates the mechanical performance degradation of aluminum alloy slotted honeycomb sandwich panels based on ABAQUS.