To satisfy the increasing need for fuel efficiency improvement, light-weight structure is crucial. The challenge of safely connecting lightweight materials has led this paper to evaluate advanced joinery methods for multi-material combinations in automotive applications, aiming to streamline the selection of suitable connection techniques. In this study, applicability and performance of five joinery methods—bolting, welding, clinch, rivet, and snap fit—are investigated. Tensile and fatigue strength are two main criteria for assessment. The results indicate that welding and bolting have the highest tensile strength. Clinching and riveting provide lower strength but easier way for assembly. Snap fit has poorest performance in tensile test but provides significant advantages in terms of manufacturability and cost-effectiveness. In order to guarantee structural integrity and safety, bolt connection and welding are the preferred methods. This study overall provides perspectives that possibly contributes to the selection of connection techniques used in the production of light vehicles, especially for multi material vehicle structures.