Driving posture is an important ergonomic criterion for ensuring the comfort of the driver. Long periods of driving can cause significant strain on body posture, especially in moving vehicles due to external factors such as motion and vibration. Incorrect driving posture can also lead to discomfort in the shoulders and arms. The purpose of this study is to monitor the activation of the biceps brachii muscle during driving in two distinct postures and two driving styles (short-corner vs. long-corner). The two steering wheel positions used in the experiment were the stretched position (posture A) and the lean-back position (posture B). Five males with two years of driving experience participated in the experiment. The results indicate that participants exhibited higher muscle activation in posture B. This posture showed a high value of RMS, suggesting that individuals use more muscle when in this position. Further research is needed to better understand how long-distance driving affects the activation of specific muscles, such as the biceps brachii. Additionally, more strategies are required to reduce the risk of skeletal and muscular problems in drivers. These results are especially beneficial for academicians and designers in the automotive sector, providing guidelines to develop an ideal sitting posture for all users.