Wound healing is a complex biological process consisting of hemostasis, inflammation, proliferation, and remodeling phases. Throughout this process, key biological events such as angiogenesis, phagocytosis, and collagen remodeling are regulated and supported by growth factors and cellular activities. The design of wound dressings plays a critical role in promoting healing, preventing infection, and reducing pain by maintaining an optimal moist environment. In this context, research focused on developing cost-effective, biocompatible, and efficient materials has gained increasing importance. Hydrogels stand out as prominent materials in wound care and healing processes due to their high water retention capacity, biocompatibility, and antibacterial properties. The high water content of hydrogels helps maintain moisture balance in the wound area, preventing tissue desiccation and accelerating the healing process, while simultaneously alleviating pain and pressure. By mimicking the extracellular matrix, hydrogels promote cell proliferation and granulation tissue formation, while minimizing scar formation and optimizing healing. Their biocompatibility makes hydrogels an ideal choice for wound healing. Additionally, the incorporation of growth factors (e.g., FGF, VEGF) and nanoparticles into hydrogel polymer matrices enhances their therapeutic effects, further improving the healing process. Through controlled drug release, antimicrobial agents, and strategies targeting biofilm, hydrogels play a crucial role in wound healing by combining tissue regeneration and infection control.