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Wound healing is a complex, tightly controlled biological process that involves four main stages: hemostasis, inflammation, proliferation, and remodelling. When these stages are disrupted by microbial infection or external stressors, healing can be delayed, potentially leading to chronic wounds. Conventional wound dressings have limited ability to fight infection and may not adequately support the intricate process of tissue regrowth. The development of biopolymer-based nanotechnology offers a novel solution, combining antimicrobial action with improved compatibility and degradability within the body. Biopolymers, including polysaccharides, proteins, and synthetic polymers, serve as adaptable frameworks for crafting sophisticated wound dressings. When integrated into nanoparticle-mediated delivery systems, they facilitate regulated drug dissemination, focused antimicrobial action, and the adjustment of cellular reactions vital for tissue restoration. Polymeric nanoparticles, hydrogels, and nanofiber-based dressings, when impregnated with bioactive compounds like antimicrobial peptides, metallic nanoparticles, and growth factors, have exhibited enhanced wound healing properties. These dressings effectively hinder bacterial settlement and biofilm development while promoting fibroblast multiplication, collagen accumulation, and angiogenesis, all of which are essential for successful tissue mending. Biopolymer wound dressings, enhanced by nanotechnology, provide numerous benefits such as moisture retention, oxygen permeability, and exudate absorption, thereby establishing an ideal environment for healing. Additionally, they lessen the reliance on traditional antibiotics, thus reducing the possibility of antimicrobial resistance. Cutting-edge progress in biomaterial engineering underscores the capacity of biopolymer-derived nanomedicines to transform wound management through expedited healing, decreased susceptibility to infection, and facilitated tissue regeneration. Future investigations should prioritize clinical implementation, guaranteeing that these novel therapies gain broad acceptance in medical practice.

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Underpinning the Therapeutic Potential of Biopolymer-Based Nano Medications in Wound Healing

  • 章节

  • 发表日期：

    2025年

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  • Amit Ghosh,
  • Amlan Das

摘要

Wound healing is a complex, tightly controlled biological process that involves four main stages: hemostasis, inflammation, proliferation, and remodelling. When these stages are disrupted by microbial infection or external stressors, healing can be delayed, potentially leading to chronic wounds. Conventional wound dressings have limited ability to fight infection and may not adequately support the intricate process of tissue regrowth. The development of biopolymer-based nanotechnology offers a novel solution, combining antimicrobial action with improved compatibility and degradability within the body. Biopolymers, including polysaccharides, proteins, and synthetic polymers, serve as adaptable frameworks for crafting sophisticated wound dressings. When integrated into nanoparticle-mediated delivery systems, they facilitate regulated drug dissemination, focused antimicrobial action, and the adjustment of cellular reactions vital for tissue restoration. Polymeric nanoparticles, hydrogels, and nanofiber-based dressings, when impregnated with bioactive compounds like antimicrobial peptides, metallic nanoparticles, and growth factors, have exhibited enhanced wound healing properties. These dressings effectively hinder bacterial settlement and biofilm development while promoting fibroblast multiplication, collagen accumulation, and angiogenesis, all of which are essential for successful tissue mending. Biopolymer wound dressings, enhanced by nanotechnology, provide numerous benefits such as moisture retention, oxygen permeability, and exudate absorption, thereby establishing an ideal environment for healing. Additionally, they lessen the reliance on traditional antibiotics, thus reducing the possibility of antimicrobial resistance. Cutting-edge progress in biomaterial engineering underscores the capacity of biopolymer-derived nanomedicines to transform wound management through expedited healing, decreased susceptibility to infection, and facilitated tissue regeneration. Future investigations should prioritize clinical implementation, guaranteeing that these novel therapies gain broad acceptance in medical practice.