What is the optimal temperature target for patients who remain unconscious after resuscitation from out-of-hospital cardiac arrest? The TTM trial sought to answer this question by comparing two temperature targets—33 °C and 36 °C—for targeted temperature management (TTM) in patients who remained unconscious following out-of-hospital cardiac arrest. This large, multicenter, randomized controlled trial (RCT) included 939 adult patients who were resuscitated after a presumed cardiac cause of arrest. Participants were randomly assigned to receive hypothermia at either 33 °C or 36 °C for 24 h, followed by slow rewarming. The study revealed no significant difference in mortality at 180 days or in neurological recovery between the groups. Adverse events, including arrhythmias and infections, were also similar. The TTM trial concluded that targeted temperature management at 33 °C did not provide a clear advantage over 36 °C, challenging previous practices and reinforcing the importance of avoiding fever in post-cardiac arrest care.