Is initial lower-volume enteral feeding safer in acute lung injury (ALI)? The EDEN trial compared initial trophic feeding (low-calorie feeding) with full enteral feeding in patients with ALI to determine the optimal nutritional strategy in the early phase of critical illness. This randomized controlled trial showed no significant difference in 60-day mortality or ventilator-free days between the two groups. Patients receiving trophic feeding experienced fewer gastrointestinal complications, such as vomiting and elevated gastric residual volumes. The study concluded that trophic feeding is a safe alternative to full enteral feeding in the first 6 days of ALI, potentially simplifying early nutritional management in the ICU.