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The administration of intravenous fluids represents a key area of practice in the management of critically ill patients. Saline (0.9% sodium chloride) often constitutes the traditional choice of fluid; however, it may be associated with hyperchloremia and acidosis due to its high chloride content (154 mmol/L). Balanced crystalloids such as Plasma-Lyte 148 are formulated to approximate plasma electrolyte composition more closely and contain buffer compounds like acetate and gluconate instead of chloride.

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Balanced Crystalloid vs. Normal Saline for Resuscitation: The BaSICS Trial

  • 章节

  • 发表日期：

    2025年

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  • Jose Chacko,
  • Donald B. Chalfin,
  • Ian Seppelt,
  • Swapnil Pawar,
  • Gagan Brar

摘要

The administration of intravenous fluids represents a key area of practice in the management of critically ill patients. Saline (0.9% sodium chloride) often constitutes the traditional choice of fluid; however, it may be associated with hyperchloremia and acidosis due to its high chloride content (154 mmol/L). Balanced crystalloids such as Plasma-Lyte 148 are formulated to approximate plasma electrolyte composition more closely and contain buffer compounds like acetate and gluconate instead of chloride.