This chapter focuses on Class I and Class II of Yang’s new classification of combined TMJ-skull base lesions as defined in Chap. 6 , i.e., lesions at the skull base with the articular fossa and/or the infratemporal fossa involved, and it discusses how the structures of the articular disc, condyle, and lateral pterygoid muscle can be preserved as much as possible when the lesion is resected. While designing and implementing complete resection of the lesion, every effort should be made to preserve the normal disc-articular-muscle complex and maximize the preservation of healthy joint tissue. So, in our practice, a personalized prosthesis is designed and manufactured according to the size of the defect and according to needs for the structural and functional reconstruction of the skull base and glenoid fossa. Such hemiarticular (skull base and articular fossa) prosthetic reconstruction should be particularly focused on: