In the current era, the technologies are rapidly increasing the electronic waste (E-waste) over the world. E-waste contributes a significant hazard of chemical pollution to the environment. The improper management of E-waste poses severe risks to both individual and global health. Addressing this issue necessitates effective recycling and removal systems for discarded electronic products. E-waste contains various metals, including common ones like copper and aluminum, valuable metallic elements like silver, gold, palladium, and platinum and harmful metallic elements like lead, mercury, and arsenic. Biological techniques, particularly those involving microorganisms, offer promising solutions for E-waste recovery and treatment. The various methods, such as biosorption, bioleaching, bioaccumulation, biotransformation, biomineralization, and microbially enhanced chemisorption, can transform harmful waste material into non-hazardous or less harmful forms. Additionally, genetically modified organisms and genetically engineered microorganisms hold the potential for future E-waste degradation. These biological methods are effective as well as very cost-efficient. The current chapter aims to encompass the application of various biological tools and techniques to enhance the bioremediation of E-waste.