Lifestyle diseases pose a significant challenge in contemporary society, and their prevalence is steadily rising. Considerable progress can be achieved by implementing minor modifications in our lifestyle and dietary practices. This chapter delineates several natural products and compounds that exhibit efficacy in addressing diverse lifestyle diseases and particularly focused on oral cancer and written in a straightforward manner that will be highly advantageous for the general public, students, and new researchers. We have examined the mechanisms and signaling pathways that significantly contribute to oral cancer. Additionally, we have explored several natural compounds that effectively suppress these processes, which can be highly informative for students and new research endeavors.