Mental health in Iran has evolved through years of sustained efforts, overcoming cultural, economic, and social barriers to expand access to care. The nation’s mental health programs have progressively developed and integrated into the primary health care system, ensuring comprehensive services from primary prevention to harm reduction initiatives. This integration is a key strength, providing accessible, structured, and continuity-based support across different levels of intervention. Despite challenges such as stigma, workforce shortages, and resource constraints, efforts continue to enhance mental health awareness and accessibility. The emphasis on community participation, structured training for health professionals, and inter-sectoral collaboration has strengthened the program’s impact. As mental health disorders remain a growing concern, Iran’s integrated approach offers a scalable and sustainable model for developing countries aiming to improve mental health care within existing healthcare systems.