In the postharvest phase, maintaining the quality and extending the shelf life of agricultural products is paramount. Gamma-aminobutyric acid (GABA) plays a crucial role in postharvest management, exploring its influence on stress alleviation, enhancement of antioxidant defense mechanisms, and modulation of key metabolic pathways. By examining the biochemical and physiological underpinnings of GABA’s action, a comprehensive understanding of how GABA can be harnessed to improve postharvest quality and reduce losses in various horticultural crops is warranted. Through this exploration, the potential for GABA-based strategies to revolutionize postharvest management practices will be highlighted, offering new avenues for research and application in the agricultural sector.