As the concluding stage in leaf development, senescence plays a fundamental role in balancing plant health and yield. Gamma-aminobutyric acid (GABA) serves as a key regulator in this process, exerting diverse functions. It interacts with plant hormones like ethylene, abscisic acid, and salicylic acid, contributing to intricate signalling networks that control both stress responses and senescence progression. Environmental conditions such as light intensity, temperature fluctuations, and nutrient status significantly affect GABA metabolism, thereby altering its role in regulating senescence. This overview also highlights recent findings on GABA-responsive receptors and transcription factors involved in signalling cascades, offering promising insights for enhancing crop performance and resilience.