This chapter examines the application of elicitors in hydroponic systems to augment nutrient absorption and boost plant resilience to stress. Hydroponic systems, a soil-free technique for plant cultivation, provide regulated surroundings that enhance growth conditions. Hydroponic farming has garnered considerable interest as an efficient, soil-less cultivation technique that offers a regulated environment for plant development. Nonetheless, enhancing plant growth and resilience within these systems continues to be a significant problem. Elicitation activities that activate plant defense mechanisms present possible strategies to improve nutrient absorption and stress resilience in hydroponic systems. Elicitors, including plant hormones, microbes, and physical stresses, can trigger various plant responses that enhance overall productivity and crop quality. The integration of elicitors into hydroponic systems optimizes nutrient supply and improves stress tolerance, presenting a viable option for sustainable agriculture. The chapter tells how elicitation processes can influence root architecture, enhance nutrient uptake, and activate defense mechanisms, so improving plants’ efficiency in addressing both biotic and abiotic stressors. Moreover, it emphasizes that nutrient solutions in hydroponics can be customized with elicitors to enhance yields, improve quality, and decrease dependence on chemical fertilizers and pesticides.