Apart from the physical impact in the form of exposure to infection, the Covid-19 pandemic also caused psychological effect, such as burnout on health workers, especially nurses as front liners. The ability to combine spirituality and work spirituality is thought to be able to strengthen the nurses’ work engagement at work to minimize burnout. The objective of this study is to analyze the impact of resilience and work spirituality on hospital nurses’ work engagement post-Covid-19 pandemic. This quantitative study approached a total of 166 nurses with ≥1 year of work experience at Unhas Hospital using analytic observational design and cross-sectional study. Nurse resilience questionnaires (CD-RISC), work spirituality, and work engagement (EES) are provided via online forms. Resilience is significantly and positively correlated with work engagement (p = 0.000 < α (0.05), r = 0.751) and has a 57.4% effect on work engagement (adjusted R-squared = 0.574). Meanwhile, work spirituality does not correlate significantly with work engagement (p = 0.114 > α (0.05)). Higher resilience scores are associated with higher work engagement score of nurses. The study reveals that work spirituality has no significant effect on work engagement.