The present chapter discusses the development and innovation of nanopesticides aimed at agriculture, emphasizing sustainable platforms that seek to reduce environmental impacts and promote more efficient and ecological farming. It addresses the environmental and health risks of using these nanopesticides, considering their ecotoxicity and potential effects on biodiversity and human health. Additionally, the chapter analyzes the complex regulatory challenges specific to these nanoplatforms, highlighting the urgent need for clear guidelines and new evaluation methods to handle the novelty and complexity of nanopesticides. In the context of risk assessment, it emphasizes the importance of rigorous scientific reports and reliable data. Finally, it discusses the prioritization and reuse of existing data as crucial strategies to accelerate the regulatory process and reduce costs, while ensuring the safety and efficacy of the nanoplatforms used in agriculture.