Pneumothorax is a critical condition characterized by the presence of air in the pleural cavity, leading to partial or complete lung collapse. In the intensive care unit (ICU), timely recognition and effective management are vital, especially in patients with respiratory distress or hemodynamic instability. This chapter provides a comprehensive approach to managing pneumothorax in the ICU, incorporating detailed indications and contraindications, procedural techniques, post-procedural care, and considerations for training and nursing perspectives [1, 2] [Ref: Algorithm 88.1].