Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a critical and potentially life-threatening event characterized by a sudden worsening of respiratory symptoms beyond normal day-to-day variations. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 guidelines, AECOPD is defined by acute symptoms such as dyspnea, cough, and sputum production that worsen in <14 days and necessitate a change in regular medication. A key feature emphasized in the updated guidelines is dynamic hyperinflation, resulting from airflow limitation and air trapping, which significantly contributes to increased dyspnea and the work of breathing during exacerbations. Common triggers include respiratory infections (viral or bacterial) and environmental factors like air pollution and exposure to toxic gases [1–3] [Ref: Algorithm 75.1].

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Approach to Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the ICU

  • Shakti Bedanta Mishra,
  • Samir Samal,
  • Sagarika Panda

摘要

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a critical and potentially life-threatening event characterized by a sudden worsening of respiratory symptoms beyond normal day-to-day variations. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 guidelines, AECOPD is defined by acute symptoms such as dyspnea, cough, and sputum production that worsen in <14 days and necessitate a change in regular medication. A key feature emphasized in the updated guidelines is dynamic hyperinflation, resulting from airflow limitation and air trapping, which significantly contributes to increased dyspnea and the work of breathing during exacerbations. Common triggers include respiratory infections (viral or bacterial) and environmental factors like air pollution and exposure to toxic gases [1–3] [Ref: Algorithm 75.1].