Nanobiosensor application in the food chain marks a positive development in the food industry about food safety quality management, and chain efficiency. This paper aims to identify the techno-economic feasibility of nanobiosensor technology for the food industry while introducing the possibility of disposing of conventional food testing systems. Potential benefits and costs, we discuss costs and benefits, the potential for further enlargement, and possible improvements of the supply chain. Furthermore, we review the underlying general properties of nanobiosensor platforms in terms of sensitivity, specificity, and fast response time. The use of these advanced sensors may result in better identification of the sources of contamination or disease-causing pathogens and minimize food-borne disease incidence among consumers. In addition, we highlight issues and constraints to the broad utilization of the concept such as regulatory concerns and technological impediments. Finally, this study reaffirms the call for cross-disciplinary fashion in realizing and deploying nanobiosensors in food systems across the value chain for better and safer food production.