This chapter investigates the problem of propellant-efficient station-keeping using a hybrid sail in the Earth-Moon system. To achieve high-precision station-keeping and minimize propellant consumption, the problem is approached from both reference orbit design and control strategy perspectives. A high-fidelity model of a hybrid sail, consisting of a solar electric propulsion (SEP) system and a solar sail equipped with reflectivity control devices (RCD), is utilized for reference orbit design in the Earth-Moon system through numerical methods. These hybrid-sail perturbed halo and Lyapunov orbits are parameterized by the sail’s reflectivity and are inherently unstable. An orbit-attitude control strategy is proposed for station-keeping, which consists of three components: a nonlinear disturbance observer (NDO)-based optimal periodic orbital controller, SEP acceleration optimization, and an NDO-based robust backstepping attitude controller. Notably, RCD is employed in both orbital and attitude control. Numerical results demonstrate that the proposed control strategy ensures high-precision station-keeping while effectively reducing propellant consumption.