At present, the cable-stayed cable of the sea-crossing bridge has adopted the pneumatic measures including spiral, surface pits and the mechanical measures of plate damper, according to relevant research, it is found that there is a certain high-mode vibration of the target cable, although the existing pneumatic and damper vibration suppression measures can play a greater role in the normal environment, but the vibration suppression effect is still not effective enough under complex wind conditions, taking a sea-crossing bridge as the engineering background, combined with the measured data of the health monitoring system, and carries out parameter optimization research on the existing damper. TMD dampers with unlimited positions are installed at the peak positions of multiple modal mode shapes to suppress high-frequency multi-modal vibrations generated by cable-stayed cables. The vibration suppression effect of the existing damper of the target cable is evaluated by using the modal installation position ratio theory. The vibration suppression measures of TMD damper are proposed, and the parameter design of TMD damper is carried out. The results indicate that the minimum modal damping ratio is 0.35%, which can achieve the purpose of suppressing the vortex vibration of the target cable. TMD dampers are very sensitive to their control frequency. When the frequency ratio is 1.02, the system damping ratio increases first and then decreases with the TMD damping ratio. When the TMD self-damping ratio is about 0.046, the maximum value of the system damping ratio is the optimal damping ratio.