This paper investigates the dynamic behaviors of a plate with multi-layer under the influence of dynamic harmonic load and temperature when resting on a varying stiffness foundation. The multi-layer plate’s governing equation, subjected to harmonic moving loads and temperature, is constructed through the principle of virtual work. This equation is then discretized by using the Moving Element Method (MEM), and the equation results are solved by employing the Newmark-Beta method. Prior to analyzing the impact of dynamic harmonic loads, varying foundation parameters, and temperature on the multi-layer plate's dynamic behavior, the proposed model undergoes validation for specific scenarios. The study reveals that increasing the angular frequency and amplitude of dynamic harmonic loads results in heightened displacement in both upper and lower plates. Conversely, higher foundation’s coefficients of the stiffness and damping contribute to a reduction in displacement within the multi-layer plate. Additionally, a rise in temperature correlates with increased displacements. Hence, these parameters warrant careful consideration during the design process and optimization of multi-layer structures.