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Cognitive dysfunction in type 2 diabetes mellitus (T2DM)Type 2 diabetes mellitus (T2DM) poses a significant peril not only to compromised human well-being but also to the onset of dementia, Alzheimer’s disease, and depression. Given the present research findings utilizing animal models, various potential biochemical mechanisms have been reported for hippocampus-based cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM). This chapter focuses on the relationship between cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM) and dysregulation of the hippocampal astrocyte-neuron lactate shuttle, with specific emphasis on monocarboxylate transporter 2 (MCT2)Monocarboxylate transporter 2 (MCT2). Furthermore, it provides a summary of the evidence suggesting the potentiality of exercise as a viable therapeutic interventionTherapeutic intervention, encompassing not solely glycemic control but also the amelioration of cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM).

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The Effects of Exercise on Hippocampus-Based Cognitive Dysfunction in Type 2 Diabetes Mellitus: A Possible Involvement of Hippocampal Monocarboxylate Transporter 2

  • 章节

  • 发表日期：

    2025年

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  • Takeru Shima,
  • Hideaki Soya

摘要

Cognitive dysfunction in type 2 diabetes mellitus (T2DM)Type 2 diabetes mellitus (T2DM) poses a significant peril not only to compromised human well-being but also to the onset of dementia, Alzheimer’s disease, and depression. Given the present research findings utilizing animal models, various potential biochemical mechanisms have been reported for hippocampus-based cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM). This chapter focuses on the relationship between cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM) and dysregulation of the hippocampal astrocyte-neuron lactate shuttle, with specific emphasis on monocarboxylate transporter 2 (MCT2)Monocarboxylate transporter 2 (MCT2). Furthermore, it provides a summary of the evidence suggesting the potentiality of exercise as a viable therapeutic interventionTherapeutic intervention, encompassing not solely glycemic control but also the amelioration of cognitive dysfunction in T2DMType 2 diabetes mellitus (T2DM).