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Wnt signaling pathway is conserved among different organisms. In Caenorhabditis elegans, transgenerational activation of Wnt ligands and transgenerational inhibition in Wnt receptors mediate induction of transgenerational pollutants toxicity. After pollutant exposure at parental generation, activated Wnt ligands have the potential to transgenerationally target to their receptors in the offspring to cause transgenerational toxicity. Transgenerational inhibition in Wnt receptors induced by pollutant exposure can lead to further transgenerational inhibition in transcriptional factor β-catenin/BAR-1 by affecting signaling cascade of Dishevelled proteins-APC complex components. Transgenerational BAR-1 inhibition results in suppression in mitochondrial unfolded protein response to mediate transgenerational pollutant toxicity by inhibiting DVE-1 expression.

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Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Wnt Signals

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  • 发表日期：

    2026年

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  • Dayong Wang

摘要

Wnt signaling pathway is conserved among different organisms. In Caenorhabditis elegans, transgenerational activation of Wnt ligands and transgenerational inhibition in Wnt receptors mediate induction of transgenerational pollutants toxicity. After pollutant exposure at parental generation, activated Wnt ligands have the potential to transgenerationally target to their receptors in the offspring to cause transgenerational toxicity. Transgenerational inhibition in Wnt receptors induced by pollutant exposure can lead to further transgenerational inhibition in transcriptional factor β-catenin/BAR-1 by affecting signaling cascade of Dishevelled proteins-APC complex components. Transgenerational BAR-1 inhibition results in suppression in mitochondrial unfolded protein response to mediate transgenerational pollutant toxicity by inhibiting DVE-1 expression.