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Both histone/DNA methylation and histone acetylation play important functions in regulating transgenerational toxicity of stresses and pollutants. Pollutant exposure could cause transgenerational response of certain forms of histone methylation. In the germline, histone methyltransferases (HMTs) and histone demethylases (HDMs) could show transgenerational response to pollutants, and some germline HMTs regulated transgenerational pollutant toxicity by modulating expression and function of their downstream targets. The germline histone acetyltransferases (HATs) and germline histone deacetylases (HDACs) could also exhibit transgenerational response to pollutants, and some germline HATs and germline HDACs regulated transgenerational pollutants toxicity by affecting expressions of their downstream targets, such as certain secreted germline ligands. Exposure to stresses and pollutants could also induce transgenerational change of DNA 6mA level and transgenerational response of DNA methyltransferase DAMT-1 and DNA demethylase NMAD-1. DAMT-1 played the important function in regulating transgenerational pollutant toxicity in the germline.

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Regulation of Transgenerational Toxicity by Germline Methylation and Acetylation–Related Signals

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  • 发表日期：

    2026年

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  • Dayong Wang

摘要

Both histone/DNA methylation and histone acetylation play important functions in regulating transgenerational toxicity of stresses and pollutants. Pollutant exposure could cause transgenerational response of certain forms of histone methylation. In the germline, histone methyltransferases (HMTs) and histone demethylases (HDMs) could show transgenerational response to pollutants, and some germline HMTs regulated transgenerational pollutant toxicity by modulating expression and function of their downstream targets. The germline histone acetyltransferases (HATs) and germline histone deacetylases (HDACs) could also exhibit transgenerational response to pollutants, and some germline HATs and germline HDACs regulated transgenerational pollutants toxicity by affecting expressions of their downstream targets, such as certain secreted germline ligands. Exposure to stresses and pollutants could also induce transgenerational change of DNA 6mA level and transgenerational response of DNA methyltransferase DAMT-1 and DNA demethylase NMAD-1. DAMT-1 played the important function in regulating transgenerational pollutant toxicity in the germline.