Synthetic bioceramics, utilizing principles and techniques from the life sciences and engineering, are integral to tissue engineering for replacing, repairing, restoring, and enhancing damaged tissues or organs. The human body comprises various tissues and organs with distinct functions, and hard tissues form the essential framework that enables mobility and movement. Skeletal muscles, which account for 40–50% of an adult’s body mass, are susceptible to injuries caused by trauma, lacerations, strains, contusions, or complications from surgical procedures. As the body ages, tissues can sustain damage or experience functional decline, necessitating surgical intervention due to their limited self-healing capabilities. Traditional treatments involve replacing damaged tissue with autologous tissue sourced locally or from distant sites, but these methods are constrained by insufficient donor tissue and risks such as donor site morbidity. Engineered scaffolds designed to use a patient’s own cells to pre-construct tissue for implantation present a promising alternative to autografts, enabling the regeneration of functional tissue in vitro. Hard tissue engineering scaffolds are developed with specific mechanical properties and structures to promote cell adhesion, growth, and differentiation, leading to the formation of functional tissue [1–3]. For certain hard tissue engineering applications, the mechanical strength, porosity, biocompatibility, bioresorbability, and non-toxicity of implant materials need improvement. Recent advancements have also focused on creating antibacterial or anti-infective biomaterials to maintain sterility and prevent infections in scaffolds or implants. These biomaterials reduce the risk of infection, especially in procedures involving open fractures or bone remodeling surgeries. Microbial infections in such cases can occur as bacteria adhere to the material surface through various mechanisms. Passive adsorption is one such method, where interactions between bacteria and the biomaterial surface facilitate adhesion [4, 5].

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Ceramics Based Artificial Tissues

  • Arnab Chanda,
  • Dishant Sharma

摘要

Synthetic bioceramics, utilizing principles and techniques from the life sciences and engineering, are integral to tissue engineering for replacing, repairing, restoring, and enhancing damaged tissues or organs. The human body comprises various tissues and organs with distinct functions, and hard tissues form the essential framework that enables mobility and movement. Skeletal muscles, which account for 40–50% of an adult’s body mass, are susceptible to injuries caused by trauma, lacerations, strains, contusions, or complications from surgical procedures. As the body ages, tissues can sustain damage or experience functional decline, necessitating surgical intervention due to their limited self-healing capabilities. Traditional treatments involve replacing damaged tissue with autologous tissue sourced locally or from distant sites, but these methods are constrained by insufficient donor tissue and risks such as donor site morbidity. Engineered scaffolds designed to use a patient’s own cells to pre-construct tissue for implantation present a promising alternative to autografts, enabling the regeneration of functional tissue in vitro. Hard tissue engineering scaffolds are developed with specific mechanical properties and structures to promote cell adhesion, growth, and differentiation, leading to the formation of functional tissue [1–3]. For certain hard tissue engineering applications, the mechanical strength, porosity, biocompatibility, bioresorbability, and non-toxicity of implant materials need improvement. Recent advancements have also focused on creating antibacterial or anti-infective biomaterials to maintain sterility and prevent infections in scaffolds or implants. These biomaterials reduce the risk of infection, especially in procedures involving open fractures or bone remodeling surgeries. Microbial infections in such cases can occur as bacteria adhere to the material surface through various mechanisms. Passive adsorption is one such method, where interactions between bacteria and the biomaterial surface facilitate adhesion [4, 5].