This chapter explains how clinical recovery protocols should be designed from a target-driven model in which the intervention is selected according to the biological problem to be modified and the endpoint used to verify change, rather than by tradition or modality label alone. It develops a practical dose-response framework centered on the interaction among temperature, pressure, exposure time, timing of application, and mechanical load, showing why these variables determine the physiological stimulus actually received by tissue. The chapter also details how protocol standardization, contextual control, and measurement reliability condition interpretability in both athlete monitoring and clinical decision-making. Particular attention is given to selecting valid microvascular, neuromechanical, symptom, performance, and biochemical endpoints, and to distinguishing mechanistic responses from clinically meaningful outcomes. The final aim is to provide a concise template for building reproducible, mechanism-based, and context-sensitive protocols that can be implemented, tested, and refined with precision.