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Despite the advances in diagnosis and treatment, cancer remains one of the deadliest diseases worldwide. Recent advances in the nanotechnology field have been a major key to developing new nanoparticle-based therapy for cancer treatment. Magnetic hyperthermia treatment is an alternative that has proven its efficiency when combined with chemotherapy/radiotherapy. Using Magnetic Nanoparticles (MNPs), cancer cells can be selectively killed by the elevation of the tumor temperature to 40–46 °C. By adjusting the size, shape and composition of MNPs it is possible to obtain a better magnetic performance. Triple-Negative Breast Cancer (TNBC) is an aggressive type of breast cancer that accounts for 15–20% of all Breast Cancer (BC) cases. A poor prognosis and a high possibility of reoccurrence and development of metastasis are some of the major problems behind TNBC. Due to the lack of hormone receptors, the standard treatment for TNBC is chemotherapy, whose cytotoxicity has led the scientific community to develop new efficient methods to treat TNBC.

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Multifunctional Magnetic Nanoparticles to Treat Aggressive Forms of Breast Cancer

  • 会议论文

  • 发表日期：

    2025年

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  • Bárbara Costa,
  • Sílvia Soreto Teixeira,
  • Fernando Mendes,
  • Manuel P. F. Graça

摘要

Despite the advances in diagnosis and treatment, cancer remains one of the deadliest diseases worldwide. Recent advances in the nanotechnology field have been a major key to developing new nanoparticle-based therapy for cancer treatment. Magnetic hyperthermia treatment is an alternative that has proven its efficiency when combined with chemotherapy/radiotherapy. Using Magnetic Nanoparticles (MNPs), cancer cells can be selectively killed by the elevation of the tumor temperature to 40–46 °C. By adjusting the size, shape and composition of MNPs it is possible to obtain a better magnetic performance. Triple-Negative Breast Cancer (TNBC) is an aggressive type of breast cancer that accounts for 15–20% of all Breast Cancer (BC) cases. A poor prognosis and a high possibility of reoccurrence and development of metastasis are some of the major problems behind TNBC. Due to the lack of hormone receptors, the standard treatment for TNBC is chemotherapy, whose cytotoxicity has led the scientific community to develop new efficient methods to treat TNBC.