In this book chapter, we explore the current research conducted at Tampere University in the Smart Photonic Materials group around the integration of azobenzenes into smart biomaterials. Such materials respond to light, allowing dynamic modulation of cell behavior. Techniques for patterning cell-instructive surfaces using light are discussed, leveraging azobenzene-based photoisomerization for spatially controlled cell attachment and migration. We delve into both static and dynamic applications: the former involve stable cell-material interactions, while the latter pose challenges related to temporal control and reversibility. Recent advances in using azobenzene materials to study intracellular calcium dynamics are highlighted, enabling real-time monitoring and manipulation of cellular responses. Additionally, we present several examples of other light-responsive materials beyond thin films, such as hydrogels and liquid crystalline networks, that hold great potential as smart biointerfaces. Finally, we briefly touch upon the transition from research to business, discussing commercialization prospects and potential applications in biotechnology and medical devices.