The chapter “Technology and De-humanization of Medicine” published in 2017 relies on the insight about the nature of modern technology since its emergence in seventeenth-century Europe and its application to the domain of modern Western medicine (today called Biomedicine) from the seventeenth to the early twenty-first century. This understanding changes at different periods, first focusing on machines such as steam engines whether pulling trains or powering cotton mills such as the Quarry Bank Mill in Cheshire, one of the best preserved textile factories of the Industrial Revolution which first occurred in England. The next stage was centered less on physics but more on biology, on organisms including the human organism during the mid-nineteenth century when Darwin published On The Origins of Species in 1859. Technological outcomes are human artifacts, the ontological contrast of organisms which are naturally occurring, and therefore independent of human manipulation. However, a profoundly radical change soon occurred in modern/Western consciousness—organisms began to be perceived and understood as machines. In medicine, the patient was regarded as nothing more than a malfunctioning machine with defective parts/organs which must then be replaced by a nondefective organ/part—surgery as a technology embodies this ontological volte-face. However, biology/genetics is fast-moving. By the early twenty-first century, this mechanistic Reductionist paradigm of scientificity was overturned by the findings of the Human Genome Project, about 50 years after the discovery of DNA genetics in 1953. Today, Reductionism in biology/genetics has muted in favor of Wholism (Noble, The music of life: biology beyond genes. Oxford University Press, Oxford, 2006/2008). The Addendum takes up this theme.