Why Is There Chaos in the Study of Odors?
摘要
Since odors are an attribute of organic compounds and their perception is a physiological act involving complex biochemical and biophysical processes, the science of olfaction is an interdisciplinary field at the intersection of chemistry, physiology, biochemistry, and biophysics. Both in the past and present centuries, these areas have been highly productive in terms of discoveries and have yielded several Nobel Prizes. However, the establishment of a new interdisciplinary science takes time, and there are phases in which specialists from the “pure sciences” work in isolation and not in coordination with one another. For example, chemists working in the field of olfaction often have little interest in receptor physiology, while physiologists have little interest in the chemical structure of substances. As a result, findings are often obtained that do not fit together. This situation is reminiscent of the anecdote about the three blind men and the elephant. For all three, it was an unknown animal. One day, they had the opportunity to touch it. One touched the ear, another the trunk, and the third the legs. When asked what the elephant was, the first replied: a large ear, the second: a large trumpet, and the third: a large foot. We cannot deny that each of them was correct, but only a sighted person can understand that these are actually parts of one and the same body. Similarly, the organic chemist sees osmophoric groups in odorants, the stereochemist sees geometric figures, the biochemist sees substrates and reactions, the physical chemist sees electromagnetic waves, the electrophysiologist sees capacitors, and so on. It is clear that the efforts of the individual specialists must be directed toward a common goal in order to grasp the process as a whole. In addition to the need for improved coordination among the various specialists, there are also objective reasons for the lag in research in the field of olfaction. Above all, there is a lack of physical instruments for measuring odors. Odor is not a physical phenomenon, but is perceived subjectively. While in auditory and visual research the parameters of the stimulus (sound and electromagnetic waves) can be measured precisely and objectively, the effect of an odorant is reported subjectively. The same substance may be perceived by one person as pleasant-smelling, by another as unpleasant, and by yet another as odorless (in the case of anosmia). The smell of gasoline serves as an example. There are people who cannot tolerate it, and others who are so addicted to it that they need to inhale several milliliters of gasoline every day. The assessment of odor intensity is also subjective and depends on the acuity of the sense of smell. It does not matter whether the person smelling is a man or a woman. However, it is known that women generally have a more developed sense of smell than men. The time of day is also important for the study of odors, as olfactory acuity fluctuates circadianly. Typically, it is stronger in the morning and weaker in the evening.