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Atomic force microscopy (AFM) provides high-resolution imaging and mechanical analysis of biological samples, ranging from single molecules to complex tissues. This chapter introduces the principles and applications of AFM in measuring topography, elasticity, adhesion, and viscoelasticity. It also covers single-molecule force spectroscopy and compares AFM with scanning ion conductance microscopy (SICM), highlighting the advantages that SICM offers for delicate samples. Using examples, the chapter illustrates how AFM and SICM can contribute to our understanding of cellular mechanics, molecular interactions, and disease-related changes in biological structures.

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Measurement of Single Molecules, Cells, and Tissues with Atomic Force Microscopy

  • 章节

  • 发表日期：

    2026年

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  • Aylin Balmes,
  • Tilman E. Schäffer

摘要

Atomic force microscopy (AFM) provides high-resolution imaging and mechanical analysis of biological samples, ranging from single molecules to complex tissues. This chapter introduces the principles and applications of AFM in measuring topography, elasticity, adhesion, and viscoelasticity. It also covers single-molecule force spectroscopy and compares AFM with scanning ion conductance microscopy (SICM), highlighting the advantages that SICM offers for delicate samples. Using examples, the chapter illustrates how AFM and SICM can contribute to our understanding of cellular mechanics, molecular interactions, and disease-related changes in biological structures.