Additive manufacturing is increasingly playing a key role in medical technology due to its design freedom. Patient-specific and functional designs are particularly crucial when using implants. In the context of such individual implants, calcium phosphate cement (CPC) is increasingly becoming the focus of research. Its speciality lies primarily in its biocompatible, osseointegrative, osteoinductive and osteoconductive properties. However, the removal of the CPC from the shape-giving contour after manufacturing is problematic. This paper therefore investigates approaches to specifically influence the adhesive properties between the CPC and the partner material, for example to take into account the removal of the CPC during the design process. Initial experiments show that—with the exception of the height of the CPC structure—geometric parameters show no significant correlation with the adhesive properties. However, an unexpected pattern in the investigation suggests that the introduction of heat and the surface roughness of the shape-giving contour could specifically influence the adhesive properties.