The topic of adapting corporate culture and generating a start-up mentality characterized by agility and entrepreneurship as a mandatory prerequisite for a successful and digitization-driven transformation is the content of this chapter. New methods for innovation and project management such as Scrum and Design Thinking are introduced and organizational suggestions are explained in the context of digitization. The IT application area should be detached from the IT organization and migrated to the specialist departments in order to account for the importance of IT as a strategic core element of the automotive industry and to gain momentum for the digital change. The shift in the importance of the CDO role away from the Chief Digital Officer towards the Chief Data Officer is also addressed, as are contemporary aspects of human resources work with new ways of training, hiring, and career development, as well as appropriate change management for a successful digital transformation.