The topic of “digital transformation” justifies the fundamental change in private and business processes, driven by the exponentially increased performance of information technology. For the automotive industry, one of Germany’s key industries, this results in an existential challenge both for strategic alignment towards new mobility services instead of vehicle ownership, and for new ways of distribution. Moreover, it is necessary to design highly efficient, digitized business processes such as Industry 4.0-based production, while utilizing new technologies like cloud computing, artificial intelligence, and also the potentials of virtual environments in the Industrial Metaverse. Building on an explanation of the essential technologies, the changed customer and market expectations, a framework for action and a holistic approach are explained, which lead to a successful transformation of the automotive industry. Practical examples complement the guide.