Following chapter 1’s exploration of blockchain’s theoretical suitability for pharmaceutical track-and-trace systems, this chapter conducts a Systematic Literature Review (in the following SLR) to chart how blockchain technology has been proposed for pharmaceutical track-and-trace systems to understand what’s been built and what still needs attention. The aim of this SLR is to map the landscape of proposed blockchain applications in PSC focusing on their role in enhancing traceability, preventing counterfeits, ensuring regulatory compliance and supply chain transparency.