This paper critically examines the concept and implementation of deradicalization and reintegration programs in the Global South, with a focus on case studies from Saudi Arabia, Yemen, Singapore, Sri Lanka, and Malaysia. Deradicalization is explored as a multidimensional process encompassing ideological rehabilitation, psychological counseling, and social reintegration. Drawing on empirical data and program evaluations, the study highlights both the strengths and limitations of various national approaches, such as Saudi Arabia’s PRAC model and Malaysia’s holistic rehabilitation modules. It also underscores the importance of family involvement, community engagement, and post-release support in ensuring long-term disengagement from extremism. The analysis emphasizes emerging trends in the field, including individualized interventions, the strategic use of technology, and the shift from ideological transformation to behavioral disengagement. Ultimately, the paper argues for evidence-based, context-sensitive, and ethically grounded deradicalization frameworks that prioritize human rights, social cohesion, and sustainable reintegration into society.