Emission simulation offers a fast way to investigate and evaluate new concepts and setups concerning the prediction of the catalytic behavior depending on boundary conditions such as temperature and emission composition. Since hydrogen engines (H2-ICE) are currently in an early stage of development and therefore their availability for measurements on the engine test bench is still very limited, the emission simulation provides an adequate opportunity to create initial designs of the exhaust gas aftertreatment system (EATS). In this study, different layouts of EATS consisting of an oxidation catalyst, a combination of vanadium and copper zeolite SCR catalysts, ammonia-slip catalyst (ASC) and particulate filter (PF) are built in a simulation environment. The simulation models of the catalytic reaction kinetics are validated with synthesis gas test bench results for hydrogen environment. As a basis for the synthetic gas test bench measurements, hydrothermal aged samples of conventional catalysts are used, also considering the high amount of water present in H2-ICE. A suitable kinetic model is chosen for each layout. As input, the measured test bench data of a WHTC hot cycle of a medium-duty research hydrogen engine is used and has been rescaled to a heavy-duty application. The resulting cumulative tailpipe emissions of NOx, N2O and H2 will be compared between the different layouts. Another aspect of this study is the impact of the urea-water-solution dosing strategy onto the cumulative emissions, which will be discussed.