Restrictive future CO2 emission regulations are incentivizing evaluation of carbon-free fuels. This is particularly true in the difficult to electrify heavy commercial vehicle segment. The development of hydrogen internal combustion (H2 ICE) for large displacement engines can both expedite hydrogen adoption and reduce total cost of ownership. This paper will cover how the application of a driven-turbo can address challenges unique to H2 ICE. This paper will build upon the simulation results presented at the International Engine Congress 2023 and compare them to new engine test results. The research being presented is joint engine testing conducted by AVL List GmbH and SuperTurbo Technologies on a 13L H2 ICE. The first H2 ICE challenge that will be addressed is the requirement for the engine to maintain a lean-burn combustion strategy. Maintaining H2 lean-burn is key to controlling NOx formation and minimizing aftertreatment requirements. The dynamic high lambda requirement can create challenges for turbocharges when available turbine power is insufficient for the desired compressor power. The on-demand air functionality of the Driven-turbo negates this problem and can be used to optimize air-fuel ratio in steady-state and transient cycles. The engine dyno test will show low NOx formation through combustion optimization and time to torque transients equivalent to diesel. The second H2 ICE challenge that will be addressed is how to maintain highest BMEP and BTE for hydrogen internal combustion engines with a driven-turbo to close the gap to diesel and FCEV respectively. The availability of driven-turbo enabled exhaust energy recovery through turbo-compounding, in combination with combustion optimization, will demonstrate an ability to improve H2 ICE BMEP/BTE/BSFC.