This chapter is intended to be a presentation of alkaloids derived by amination reaction (acetate-derived) from chemical, biological, and ecological points of view. The phytochemistry, isolation, biosynthesis, and biological activities of these alkaloids are described. The acetate-derived alkaloids (coniine) are contained mainly in the plant poison hemlock (Conium maculatum); therefore, some of the botanical characteristics of this plant are mentioned. It is, however, pertinent to mention at this juncture that the enormous volume of authentic information accumulated so far with regard to the isolation of alkaloids from a variety of plant species and their subsequent characterization by the help of the latest analytical techniques may be classified as alkaloids derived from amination reactions. These include: