Scholarlink

Natural products remain a vital source of bioactive molecules, offering novel interactions with both known and unexplored pharmacological targets. Among these, menthol has attracted significant attention due to its wide spectrum of biological activities. Studies have highlighted its role in generating inward cationic currents linked to temperature sensing, primarily through the activation of TRPM8 ion channels. This chapter explores menthol’s pharmacological properties across various tissues, emphasizing its cytotoxic effects. Evidence suggests that these effects are closely tied to TRPM8 activation and intracellular calcium dynamics, shedding light on its therapeutic potential and mechanisms of action.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Menthol: Biological Effects and Toxicity

  • 动态工具书词条

  • 发表日期：

    2025年

查看全文
  • Darizy F. Silva,
  • Fênix A. Araújo,
  • Humberto C. Joca,
  • Camila Dourado,
  • Demétrius A. M. Araújo,
  • José H. Leal-Cardoso,
  • Jader S. Cruz

摘要

Natural products remain a vital source of bioactive molecules, offering novel interactions with both known and unexplored pharmacological targets. Among these, menthol has attracted significant attention due to its wide spectrum of biological activities. Studies have highlighted its role in generating inward cationic currents linked to temperature sensing, primarily through the activation of TRPM8 ion channels. This chapter explores menthol’s pharmacological properties across various tissues, emphasizing its cytotoxic effects. Evidence suggests that these effects are closely tied to TRPM8 activation and intracellular calcium dynamics, shedding light on its therapeutic potential and mechanisms of action.