Stroke and cancer have significant morbidity and mortality with heterogeneous risk factors. While conventional risk factors such as atherosclerosis and cardiac disease are important mechanisms in the occurrence of stroke, cancer is an unconventional risk factor that leads to both ischemic and hemorrhagic stroke in a myriad of ways. Although cancer-associated strokes have unique underlying mechanisms, the clinical features, diagnosis, and management scheme are similar for non-cancer-associated strokes. Prognosis is complex and is dependent on the stage and type of cancer, expected treatment course, and stroke burden.