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Cancer therapies, including chemotherapy, immune checkpoint inhibitors, and radiation, can cause severe pulmonary side effects affecting the parenchyma, airways, pleura, and vasculature. These side effects often mimic infections, malignant disease, and other inflammatory conditions, making the diagnosis of treatment-related lung injury challenging and potentially delayed. Severe, life-threatening cases may require multiple treatments, including intensive care support, while milder cases can be addressed with dose adjustment or therapy cessation. Awareness of these potential toxicities, combined with a collaborative, multidisciplinary approach, is essential for prompt diagnosis and timely intervention.

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Pulmonary Manifestations of Adverse Events Related to Cancer Treatments

  • 动态工具书词条

  • 发表日期：

    2026年

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  • Katherine V. Dudamel,
  • Mtanis Khoury,
  • Saadia A. Faiz,
  • Ajay Sheshadri

摘要

Cancer therapies, including chemotherapy, immune checkpoint inhibitors, and radiation, can cause severe pulmonary side effects affecting the parenchyma, airways, pleura, and vasculature. These side effects often mimic infections, malignant disease, and other inflammatory conditions, making the diagnosis of treatment-related lung injury challenging and potentially delayed. Severe, life-threatening cases may require multiple treatments, including intensive care support, while milder cases can be addressed with dose adjustment or therapy cessation. Awareness of these potential toxicities, combined with a collaborative, multidisciplinary approach, is essential for prompt diagnosis and timely intervention.