Cancer is prevalent in society and many oncological surgeries result in a tissue defect. Reconstructive surgery to restore the function and shape of the resected tissue is often required. The radial forearm free flap, vertical rectus abdominis myocutaneous flap, transverse rectus abdominis myocutaneous flap, deep epigastric inferior perforator flap, and anterolateral thigh flap are commonly used for oncological reconstruction surgery. Free flaps are particularly vulnerable to prolonged ischemia. Most complications to flaps occur in the first 3 days postoperatively. Monitoring of the flap is critically important. Physical assessment of the flap site should include: capillary refill, skin color, temperature, and turgor, and presence of arterial blood flow by Doppler will identify changes in tissue perfusion. Measures should be taken to ensure adequate perfusion pressure to the surgical flap. Reconstructive surgeries with free flaps have success rates of 91–99%.