Nosocomial infections or healthcare-acquired infections are a common cause of increased morbidity and mortality among hospitalized patients. Cancer patients are at an increased risk for these infections due to their immunosuppressed states. Considering these adverse effects on and the socioeconomic burden, efforts should be made to minimize the transmission of these infections and make the hospitals a safer environment. These infection rates can be significantly reduced by the implementing and improving compliance with the “care bundles” and antibiotic stewardship. This chapter will address the common nosocomial infections such as ventilator-associated pneumonia, catheter-associated urinary tract infections, surgical site infections, Clostridioides difficile, and nosocomial meningitis including preventive strategies for the same.