“Occupational skin infections” are rarely life threatening, but they may be decapacitating, lead to incapacity to work, and cause considerable costs. Occupational skin infections are caused by bacteria, viruses, fungi, or parasites. Primary skin infections should be distinguished from those secondary to pre-existing occupational dermatoses or pre-damaged skin and colonization of skin or mucous membranes with multiresistant or potentially hazardous infectious agents in context of occupational activity. When an occupational skin infection is suspected, a detailed history needs to be taken, including information on the workplace and its conditions. This is important to understand the causal relation between the occupational situation and the infection.