Platelets play a crucial role in thrombosis and normal hemostasis. In addition to the effects of antiplatelet drugs, qualitative platelet dysfunction can result from rare inherited disorders that disrupt key processes such as platelet adhesion, activation, secretion, and aggregation. Bernard-Soulier syndrome and Glanzmann thrombasthenia are inherited platelet function disorders characterized by defects in platelet membrane glycoproteins. Clinically, these conditions often appear in early childhood with mucocutaneous bleeding, including gum bleeding, prolonged bleeding after exfoliation of primary teeth, and bleeding during the eruption of permanent teeth. Because of the significantly increased risk of perioperative and postoperative bleeding, any invasive dental procedure in affected patients requires careful treatment planning, consultation with the patient’s hematologist, appropriate systemic perioperative treatment, and the use of effective local hemostatic measures.